Melting Point (ester): 98 - 104 C

If you miss a dose of tamoxifen, do not take the missed dose at all and do not double the next one. Instead, go back to your regular dosing schedule and check with your doctor.

0.4 x pound (body weight) x days=number of tablets to take overall during the interval of intake mg / tablet.

Nolvadex is used to treat breast cancer in women or men. Tamoxifen may also be used to treat other kinds of cancer, as determined by your doctor.

Effective Dose (Women): 50-100mgs/week

More information about Anavar (Oxandrolone):

Like all medicines, VIAGRA can cause some side effects. These effects are

usually mild and do not last long. Some of these side effects are more likely to occur with higher doses. VIAGRA is generally well tolerated. Side effects are rare, but if experienced they are usually mild and temporary.

    Androgenic: Anabolic Ratio:N/A

Cypionate = C8 H4 O = 124.2mg = 69.90mg

Cytomel is not a steroid, but more a of a cutting aid. It's a synthetic form of the thyroid hormone tri-iodio-thyronine or T3, made up of a metabolite of the amino acid tyrosine and 3 iodine ions.

Close attention to diet is extremely important in people using insulin, whether this is for

legitimate medical purposes or for other reasons. You can reduce your risk by consuming an adequate amount and mixture of high and low G.I. carbohydrate foods and drinks immediately after using insulin and at regular intervals (every 2-3 hours) throughout the day.

The writer would like to emphasize once more that this paper should in no way be construed as an encouragement to people to use insulin in an effort to increase muscle mass, sports performance or appearance. Rather, it represents a pragmatic attempt at providing harm reduction advice to people who choose to take the risk of using insulin in this way, despite

their knowledge of those risks.

For years, the steroid black market has been the only supply source for athletes to get Dianabol where, proverbially, D-bol is available in all colors, forms, sizes, and under any imaginable name. Those, however, who are only interested in original compounds,should make sure that the selected compound is part of the list with common trade marks for methan-drostenolone (methandienone) or that the compound looks like the one in the photos following this description. According to our experience the Thailandian Anabol tablets and the Indian Pronabol-5 are the best compounds. The "Thai-landians",

as they are often called by their users, can be easily identified. They are pentagonally shaped, of pink color and indented. One thousand tablets are packaged in a plastic bag which is contained in a labelled plastic box the size of a drinking glass. Note that the manufacturing date and not the expiration date is printed on the label. The plastic box is usually also shrink-wrapped. The price for a 1000-package lies around $500-$ 1000 on the black market. The Indian Pronabol-5, simply called "Pronas", is enclosed in an oblong box with ten strips of 10 tablets each. These tablets are round, white, and indented on one side. The
original Pronas can be easily recognized since they come in a silver aluminum strip with a double bottom, and have a purple irnprint so that the tablets are invisible. Since the fake Pronabols are indented as well one must make certain not to purchase tablets in bulk or tablets contained in a normal push-through strip. Original Pronas, cost approximately $ 100 per package on the black market. Other easily available original compounds are the Polish Metanabol and the Czech Stenoion.

Package: 50 tabs (1 mg/tab).

    Active Life: up to 24hours

For use in cycles with testosterone, I

don't think it is bad at all. One simply doesn't want less DHT than normal. As the amount of testosterone in the system increases, the amount of finasteride needed to keep levels down to normal increases. I consider 5 mg/day reasonable at the gram per week level, and proportionally less at lower dosages of testosterone.

Sustanon 250 is an oil-based injectable Testosterone blend. Sustanon developed by the international drug firm Organon. The substance typically contains four different Testosterone esters: Testosterone propionate (30 mg); Testosterone phenylpropionate (60 mg); Testosterone isocaproate (60mg); and Testosterone

decanoate (100 mg), although a lower dosed version is also produced. An intelligently "engineered" Testosterone, Sustanon is designed to provide a fast yet extended release of Testosterone. The propionate and phenylpropionate esters are quickly utilized, releasing into circulation within the first four days. The remaining esters are much slower to release. Sustanon stayes active in the body for about two and three weeks (respectively). This is a big improvement of Sustanon from standard Testosterones such as cypionate or enanthate, which provide a much shorter duration of activity, and a more variable blood level.

This results in a dramatically improved hardness and sharpness of the muscles. One must, however, make a distinction here since Masteron does not automatically improve the quality of muscles in everyone. A prerequisite is that the athlete's fat content must already be very low. In this case Masteron can then be the decisive factor between a smooth, flat muscle or a hard and ripped look. For this purpose Masteron is often only used during the last four weeks before a competition so that the muscles get the last "kick." Masteron is especially effective in combination with steroids such as Winstrol, Parabolan, Primobolan,

Oxandrolone and also Testosterone propionate. The usual dosage taken by athletes is around 100 mg three times per week. Since the substance drostanolone propionate is quickly broken down in the body, frequent and regular injections are necessary. This fact makes Masteron a very interesting steroid when doping tests must be passed by a negative urine analysis. Since the propionate substance of drostanolone does not remain in the body very long in a sufficient, detectable amount, athletes inject the compound with great success up to two weeks before a test. However, since it also has anabolic characteristics and thus helps the

build up of a high-qualitative muscle system, the use of Masteron is not only limited to the preparation stage for a competition. Athletes who want to avoid water retention and who readily have a problem with an elevated estrogen level, likewise appreciate Masteron. Also in this case usually one ampule (100mg) is injected every second day. In combination with Primobolan, Winstrol or Testosterone propionate no enormous strength and weight gains can be obtained, only high-quality and long-lasting results. Although women do not use Masteron very often some national and international competing female athletes do take it before a championship.

Xenical (Orlistat)

The question of the right dosage, as well as the type and duration of application, is very difficult to answer. Since there is no scientificresearch showing how STH should be taken for performance improvement, we can only rely on empirical data, that is experimental values. The respective manufacturers indicate that in cases of hypophysially stunted growth due to lacking or insuffieient release of growt hormones by the hypophysis, a weekly average dose of 0.3 I.U/ week per pound of body weight should be taken. An athlete weighting 200 pounds, therefore, would have to inject 60 I.U.

weekly. The dosage would be divided into three intramuscular injections of 20 I.U. each. Subcutaneous injections (under the skin) are another form of intake which, however would have to be injected daily, usually 8 I.U. per day. Top athletes usually inject 4-16 I.U./day. Ordinarily, daily subcutaneous injections are preferred. Since STH has a half life time of less than one hour, it is not surprising that some athletes divide their dail dose into three or four subcutaneous injections of 2-4 I.U. each. Application of regular small dosages seems to bring the most effective results. This also has its reasons: When STH is injected,
serum concentration in the blood rises quickly, meaning that the effect is almost immediate. As we know, STH stimulates the liver to produce and release somatomedins and insulin like growth factors which in turn effect the desired results in the body. Since the liver can only produce a limited amount of these substances, we doubt that larger STH injections will induce the liver to produce instantaneously a larger quantity of somatomedins and insulin-like growth factors. It seems more likely that the liver will react more favorably to smaller dosages. If the STH solution is injected subcutaneously several consecutive times at the

same point of injection, a loss of fat tissue is possible. Therefore, the point of injection, or even better, the entire sisde of the body should be continuously, changed in order to avoid a loss of local fat tissue (lipoathrophy) in the injection cell. One thing has manifested itself over the years: The effect of STH is dosage-dependent. This means either invest a lot of money and do it right or do not even begin. Half-hearted attempts are condemned to failure Minimum effective dosages seem to start at 4 I.U. per day. For comparison: the hypophysis of a healthy; adult, releases 0.5-1.5 I.U. growth hormones daily. The duration
of intake usually depends on the athlete's financial resources. Our experience is that STH is taken over a prolonged period, from at least six weeks to several months. It is interesting to note that the effect of STH does not stop after a few weeks; this usually allows for continued improvements at a steady dosage. Bodybuilders who have had positive results with STH have reported that the build-up strength and, in particular, the newly-gained muscle system were essentially maintained after discontinuance of the product. It remains to be clarified what happens with the insulin and LT-3 thyroid hormone. Athletes who take STH in

their build-up phase usually do not need exogenous insulin. It is recommended, in this case, that the athlete eats a complete meal every three hours, resulting in 6-7 meals day. This causes the body to continuously release insulin so that the blood sugar level does not fall too low. The use of LT-3 thyroid hormones, in this phase, is carried out reluctantly by athletes. In any case, you must have a physician check the thyroid hormone level during the intake of STH. Simultaneous use of anabolic /androgenic steroids and/or Clenbuterol is usually appropriate. During the preparation for a competition the use of thyroid hormones steadily
inereases. Sometimes insulin is taken together with STH, as well as with steroids and Clenbuterol. Apart from the high damage potential that exogenous insulin can have in non-diabetics, incorrect use will simply and plainly make you "FAT! Too much insulin activates certain enzymes which convert glucose into glycerol and finally into triglyceride. Too little insulin, especially during a diet, reduces the anabolic effect of STH. The solution to this dilemma? Visiting a qualified physician who advises the athlete during this undertaking and who, in the event of exogenous insulin supply, checks the blood sugar level and urine periodically.
According to what we have heard so far, athletes usually inject intermediately-effective insulin having a maximum duration of effect of 24 hours once a day. Human insulin such as Depot-H-Insulin Hoechst is generally used. Briefly-effective insulin with a maximum duration of effect of eight hours is rarely used by athletes. Again a human insulin such as H-Insulin Hoechst is preferred.

In striving to become bigger, stronger, more competitive or more physically attractive you should also remember that no matter what you do, your genetic make-up will have an influence on what you are able to achieve. It is important to realize

that you cannot look exactly like the role model you admire because you have inherited a different set of genes.

Special precautions for use in children:

Chem. Abstr. Name: 17beta-Hydroxyestra-4,9,11-trien-3-one (Trenbolone Base + Acetate Ester)

It tells us that we should use IGF-1 to make more muscle cells. It's the only thing that can give it to us and more cells is more growth, which is our goal.

Clomid is an effective antagonist in the hypothalamus and in breast tissue. It is an effective agonist in bone tissue, and for improving blood cholesterol.

Male athletes also find Clomid

interesting. In men using Clomid, the elevation in both follicle stimulating hormone and (primarily) luteinizing hormone will cause natural testosterone production to increase. This effect is especially beneficial to the athlete at the conclusion of a steroid cycle when endogenous testosterone levels are depressed. If endogenous testosterone levels are not brought beck to normal, a dramatic loss in size and strength is likely to occur once the anabolics have been removed. Clomid can play a crucial role in preventing this crash in athletic performance.

Sustanon is usually injected at least once a week., which can be stretched

up to 10 days. The dosage in bodybuilding and powerlifting ranges from 250 mg every 14 days up to 1000 mg or more per day. Since such high dosages are not recommended and fortunately are also not taken in most cases the rule is 250-1000 mg/week. A dosage of 500 mg/week is completely sufficient for most, and can often be reduced to 250 mg/week by combining with an oral steroid.

Dosing Schedule

When first introduced in 1960 dianabol aquired a winning reputation among top atheletes. It was called the breakfast of Champions and dianabol soon became the most favoured and most used anabolic steroid of all disciplines.

5mg tablets are pink pentagon shaped tablets, with snake&arrow imprinted on one side.

This preparation is designed solely for parenteral use only after addition of drugs that require dilution or must be dissolved in an aqueous vehicle prior to injection, such as hGH and hCG

Clenbuterol works very effectively as a fat burner. It does this by slightly increasing the body temperature. The rise is not usually dramatic, a half of a degree, sometimes a little more but rarely more than one degree. This elevation is due to the body will burn excess energy (largely from fat) and is usually not uncomfortable.

A number of reports have documented diazepam causing interstitial nephritis, although this is considered a rare adverse effect.

It is important to stress that a cycle should last no longer than 6 weeks and it should never be halted abruptly. As slowly as the dosage was built up it should also be lowered, one tablet every 3-4 days. Taking CytomelŽ for too long and/or at too high a dosage can result in a permanent thyroid deficiency. After doing such, one might need to be treated with a drug like CytomelŽ for life. It is also a good idea to first consult your physician and have your thyroid function tested. An

undiagnosed hyperfunction would not mix well with the added hormone. An athlete should also be sure never to purchase an injectable form of the drug. It is generally an emergency room product, much too powerful for athletic use. Since T-3 is the most powerful thyroid hormone athletes are using, this is generally not the starting point for a beginner. Before using such a powerful item, it is a good idea to become familiar with a weaker substance. The highly popular Triacana is very mild, allowing the user much more latitude (from severe side effects) than CytomelŽ. An in-between point is Synthroid (synthetic T-4), still weaker in action
than CytomelŽ. Once the user is ready however, the fat burning effect of this hormone can be extremely dramatic.

Generic Name: 4 testosterones

Individuals between the ages of 18 and 75.

Trenbolone also has a very strong binding affinity to the androgen receptor (A.R), binding much more strongly than testosterone. This is important, because the stronger a steroid binds to the androgen receptor the better that steroid works at activating A.R dependant mechanisms of muscle growth. There is also strong supporting evidence that compounds which bind very tightly to the androgen receptor also aid in fat loss.

Think as the receptors as locks and androgens as different keys, with some keys (androgens) opening (binding) the locks (receptors) much better than others. This is not to say that AR-binding is the final word on a steroid´s effectiveness. Anadrol doesn´t have any measurable binding to the AR& and we all know how potent Anadrol is for mass-building.

Rather than waiting to the end of a workout, many athletes prefer to inject their insulin dosage 30 minutes before their training session is over and then consume a carbohydrate drink immediately following the workout. This will make the insulin more efficient at bringing

glycogen to the muscles, but it will also increase the danger of hypoglycemia. Some athletes will even inject a few IUs before lifting to improve their pump. This practice is extremely risky and best left to athletes with experience using insulin. Finally, some athletes like to inject insulin upon waking in the morning. After the injection, they will consume a carbohydrate drink and then have breakfast within the next hour. Some athletes find this application of insulin very beneficial for putting on mass, while others will tend to put on excess fat using insulin in this way.

2. Before starting Roaccutane Treatment

Pregnyl by Organon. 1,500 to 20,000 IU (International Units) per 10 cc vials. HCG is not a steroid but it is widely used in athletics today. HCG Prengyl is a natural protein hormone secreted by the human placenta and purified form the urine of pregnant women. This hormone is not a natural male hormone but mimics the natural hormone LH (Luetinising Hormone) almost identically. This LH stimulates the production of testosterone by the testis in males. Thus HCG sends the same message and results in increased testosterone production by the testis due to its effect on the leydig cells of the testis.

Androfort-Richt. 10,

25 mg/ml; Gedeon Richter HU

 - Your dermatologist will also measure your liver enzymes with the blood tests because roaccutane also increases these enzyme levels. If your liver enzymes remain high then your dermatologist can lower your dose or stop your treatment.

When first introduced in 1960, dianabol acquired a winning reputation among top atheletes. It was nick named "The Breakfast of Champions" and dianabol soon became the most favored and most used anabolic steroid by atheletes of all disciplines.

Enhanced sexual performance

Drug Class: Anabolic/Androgenic Steroid

Side effects

like hot flashes, menstrual irregularities and a variety of complications with the reproductive system are all possible.

Proscar and Propecia are forms of Finasteride

The third reason for the popularity of Anavar is that oxandrolone does not influence the body's own testosterone production.

Testosterone enanthate is an oil based injectable steroid, designed to release testosterone slowly from the injection site (depot). Once administered, serum concentrations of this hormone will rise for several days, and remain markedly elevated for approximately two weeks. It may actually take three weeks for the action

of this drug to fully diminish. For medical purposes this is the most widely prescribed testosterone, used regularly to treat cases of hypogonadism and other disorders related to androgen deficiency. Since patients generally do not selfadminister such injections, a long acting steroid like this is a very welcome item. Therapy is clearly more comfortable in comparison to an ester like propionate, which requires a much more frequent dosage schedule.

If overdose of Viagra is suspected, contact your local poison control center or emergency room immediately.

Possible side effects

Testosterone suspension is

an injectable preparation containing unesterfied testosterone in a water base. Among athletes, testosterone suspension has a reputation of being an extremely potent injectable, often ranked highest among the testosterones. Very fast acting, testosterone suspension will sustain elevated testosterone levels for only 2-3 days. Athletes will most commonly inject "suspension" daily, at a dosage of 50-100 mg. Although this drug requires frequent injections, it will pass through a needle as fine as a 27 gague insulin. This allows users to hit smaller muscles such as delts for injections. Although this drug is very effective for
building muscle mass, its side effects are also very extreme. The testosterone in this compound will convert to estrogen very quickly, and has a reputation of being the worst testosterone to use when wishing to avoid water bloat. Gynocomastia is also seen very quickly with this drug, and quite often cannot be used without an anti-estrogen. Blood pressure and kidney functions should also be looked at during heavy use. Suspension is not a common drug outside the U.S. and Canada, so with the disappearing "real" American versions, availability has become very scarce. There are currently many fakes being circulated, with real
products seen only rarely. Since this is a water based injectable, I would be very wary of using a counterfeit. It is more likely bacteria would be a problem with water based products and if the fake was not made to laboratory standards (most are not) your health could be at risk.

Average Dose: Men 50-150 mg/day

Those not worried about drug screens are likely to find the low water retention and good effect of this drug favorable for use in pre-contest cutting stacks. A combination of Deca and Winstrol during the weeks/months leading up to a show for example, is noted to greatly enhance to look of muscularity and definition.

A strong non-aromatizing androgen like Halotestin or trenbolone could be further added, providing an enhanced level of hardness and density to the muscles. Being an acceptable anabolic, Deca can also be incorporated into bulk cycles with good results. The classic Deca and Dianabol cycle has been a basic for decades, and always seems to provide excellent muscle growth. A stronger androgen such as Anadrol or testosterone could also be substituted, producing greater results. When mixed with Deca, the androgen dosage can be kept lower than if used alone, hopefully making the cycle more comfortable. Additionally one may choose

to continue Deca for a number of few weeks after the androgen has been stopped. This will hopefully harden up some of the bloat produced by the androgen, giving a more quality appearance. Remember that endogenous testosterone production will not resume during Deca therapy, and ancillaries are likewise still needed.

Drug Class: Highly Anabolic/Androgenic Steroid (Oral)

5-10 Units of a short acting preparation may have little or no observable impact on someone who eats a meal soon before or after but this dose could cause hypoglycemia and collapse in a person who has not consumed adequate food in close proximity to

the time when the insulin begins to take effect (insulin starts to take effect within 5-10 minutes if injected by intra-muscular route and in 30-60 minutes if injected by subcutaneous route). Foods with a high glycemic index will maintain the blood glucose level for a short period of time, perhaps an hour or so whilst those with a low glycemic index will provide for more sustained glucose levels. Risk Reduction Advice:

Masteron is a steroid highly valued by competing bodybuilders. The great popularity of this injectable steroid in bodybuilder circles is due to the extraordinary characteristics of its included substance.

Drostanolone propionate is a synthetic derivative of dihydrotestosterone. This causes the Masteron not to aromatize in any dosage and thus, it cannot be converted into estrogens. This distinctive feature is confirmed by the Belgian manufacturer, Sarva Syntex, who on the enclosed package insert calls Masteron a steroid with strong, antiestrogenic characteristics. Since Masteron is a predominantly androgenic steroid, the athlete can increase his androgen level without also risking an increase in his estrogen level.

by Bill Roberts - This drug appears to be comparable to nandrolone in its potency. It lacks nandrolone's advantage

of being metabolically deactivated by 5 a -reductase. It is only slightly estrogenic, and only after conversion to estrogen. I cannot at the moment comment on whether the effect it does produce is owed to strong binding at the AR or to effectiveness in promoting non-AR-mediated mechanisms for growth. I wouldn't expect much results with less than 400 mg/week. With that dose I would expect to see some noticeable but not dramatic results by the third week. Below 200 mg/week I would expect to see essentially nothing.

A Natural Method of Maintaining an Elevated Blood Insulin Level:

by Bill Roberts - Unlike most oral

steroids, which are Class II steroids giving most of their anabolic effect by means other than the androgen receptor (AR), it seems that oxandrolone probably does have good binding to the AR, and is therefore a Class I steroid, while having little other effect. By itself it is considered to be a weak anabolic.

If overdose of dianabol is suspected, contact your local poison control center or emergency room immediately.

Stanozolol comes in 50 mg/cc, 2 mg/tab or 5mg/tab. Winstrol Depot is manufactured by Winthrop in USA and by Zambon in Europe. Winstrol depot is very popular anabolic steroid and is a derivative of DHT.

It is a relatively low androgenic steroid which does not seem to aromatize. It can be toxic to the liver in excessive dosages. Very few user report water retention or any other side effects. It is a popular all purpose steroid; many stack with Primobolan depot for cutting, others stack it with testosterone for size and strength gains. Women often use winstrol depot but occasionally it can cause virilization, even at low dosages. Users report that the muscle gains they make are solid, they are well retained after the drug use is discontinued.

Molecular Weight: 412.6112

by Bill Roberts - This substance, used in

some Australian veterinary products, is to be avoided by male bodybuilders. It is highly estrogenic, and has no redeeming properties. It is a poor anabolic and the mythical "receptor-cleaning" properties that have been claimed for it are pure fantasy.

Cypionate = C8 H4 O = 124.2mg = 69.90mg

The rate of aromatization of this kind of testosterone is quite great, so water retention and fat gain are a fact and gyno can be a problem. If problems occur one is best to start on 20 mg of Nolvadex per day and stay on that until problems subside. I wouldn't stay on it for a whole cycle, as it may reduce the gains.

Testosterone is one of the few compounds where Proviron may actually be preferred over Arimidex. The Proviron will not only reduce estrogen and can be used for extended time on a testosterone cycle, it will also bind with great affinity to sex-hormone binding proteins in the blood and will allow for a higher level of free testosterone in the body, thus improving gains. The typical side effects can include nausea, acne, excitation or increased aggressiveness, chills, hypertension, increase in libido.

Decrease HPTA function: Yes, extreme

Since Trenbolone binds so tightly to androgen receptors, and those receptors

are found in lipid cells as well as muscle cells (10), Trenbolone seems to have a profound effect on the AR in both of these types of cells to catalyze anabolism as well as lipolysis (fat-burning) (11). Finally, Trenbolone significantly promotes red blood cell production and also increases the rate of glycogen replenishment, both of which serve to profoundly improve recovery. (12)

In some cases, women have had virilization problems with oral Winstrol at only 2 mg/day. Thus, it cannot be assumed that even a single tab per day is necessarily safe for all women concerned about maintaining their natural voice, avoiding hirsutism,

etc.

The use of anadrol should never exceed six weeks. After discontinuing the use of anadrol, it is important to continue steroid treatment with another compound since, otherwise, a drastic reduction of muscle mass and strength takes place and the user. Athletes continue their treatment with injectable testosterone such as Sustanon 250 or Testosterone Enanthate for several weeks.

T Vitis (o.c.) 10, 25 mg/ml; Neopharma G

Diazepam can cause physical and psychological dependence, and should be used with extreme caution in patients with known, suspected, or a history of substance abuse.

In order

to achieve a visible fat-reducing effect most athletes must usually take 10-14 tablets/day. Generally, two 0.35 mg tablets are taken on the first day of intake and with two tablets added each successive day until 10-14 tablets/day are taken. The half-life time of tiratricol is 5-7 hours, so Triacana is usually taken 3-4 times daily. This guarantees a constant quantity of the sub-stance in the blood and thus a continued effect. Many athletes, in the meantime, are combining Triacana with Clenbuterol or Ephedrine and report considerably better fat breakdown than when Triacana alone is taken. Among competing female bodybuilders and
participants at the Miss Fitness pageant, in particular, the simultaneous administration of 8-10 Triacana tablets/day and 80-100 mcg Clenbuterol/day is a favorite. A series of bodybuilders use Triacana in combination with growth hormones in order to meet the body's increased thyroid hormone need during STH treatment (see chapter "Growth Hormones"). The theoretical approach seems to be correct but Triacana is not an "ideal" thyroid hormone drug. The preparation Thyreocomb from the German Berlin-Chemie Company taken with a combination of the iodiferous L-T3 and L-T4 thyroid hormones would be more suit-able.

Primobolan Acetate is a naturally occurring hormonal analog that is orally bioavailable and active in it’s original form. This new class of hormone analog does not require conversion into another form of synthetic testosterone like most pro-hormones. Primobolan Acetate orals stimulate the natural production of total and active testosterone. It does this by regulating estrogen biosynthesis which produces a signal in the body to promote luteinizing hormone (LH) and decrease (SHBG) in order to increase natural production of testosterone while simultaneously stimulating free or active testosterone.

Highlights:

Inhibits estrogen formation.
Orally active in its original form, No conversion necessary
Stimulates natural production of total and free testosterone
Long term use recommended - Does not need to be cycled
Does not breakdown into banned substances or metabolites
Promotes fat free mass, strength and endurance
Can be taken alone or may be stacked with other steroids & pro-steroids

The chemical term 4-Androstenoldione Acetate refers to the isomer: 4-Androsten-4-ol-3beta,17beta-dione Acetate. 4-Androstenoldione Acetate is the acetate ester derivative of 4-Hydroxy-4-Androstenedione, which is an analog or derivative of the naturally occurring precursor hormone 4-Androstenedione. This compound concerns the isomer form of 4Androsten-4-ol-3beta,17beta-dione Acetate.

4-Androstenoldione Acetate is a steroidal aromatase inhibitor that inhibits estrogen biosynthesis, increases natural production of total and free testosterone, and may inhibit DHT formation. It does this by inhibiting the Cytochrone P-450 enzyme, which converts testosterone to estrogen. Once estrogen levels fall a signal is sent to the hypothalamic pituitary axis to produce (LH) luteinizing hormone and decrease (SHBG) steroid hormone binding globulin. LH then stimulates the testes to increase total testosterone production, in which a large portion is free or active testosterone due to the decrease in SHBG. This increased amount of testosterone is then metabolized with less estrogen and DHT conversion.

The compound is mainly eliminated by metabolism, renal excretion of metabolites accounting for 95% of dose. The excretory balance of 14C-compounds in urine and feces totals up to 98.9+/-0.8% of the i.v. dose after 168 h. The 14C-compounds in plasma and urine were separated by HPLC, and three major metabolites were submitted to structural analysis by MS, NMR and UV spectroscopy. One of the metabolites is the direct 4-O-glucuronide of formestane. The other two represent 3-O-sulfates of the exocons 3beta,4beta-dihydroxy-5alpha-androstane-17-one and 3alpha,4beta-dihydroxy-5alpha-androstane-17-one, their ratio being 7:3. These exocons are formed by stereoselective 3-keto reduction, accompanied by reduction of the 4,5-enol function. The exocons do not inhibit human placental aromatase activity in vitro.

The half-life orally was approximately 3 h, whereas the apparent half-life of injected drug was between 5 and 10 days after a more rapid clearance during the first 4 days after injection. The formulated material achieved a significantly higher mean peak concentration (88% greater than that obtained using the unformulated powder) and a higher mean AUC (not significant). The median time to peak was 1.5 h for both preparations and the elimination rate constants were similar (0.31 for micronized 4-OHA and 0.36 h-1 for formulated 4-OHA). Significant biological activity was demonstrated with the formulated material in its suppression of plasma oestradiol levels.

Another interesting note is the ability of 4-Androsten-4-ol-3, 17-dione acetate to directly stimulate testosterone whether in the presence of LH or not. Researchers examined the effects of placebo, luteinizing hormone (LH), 4-acetoxy-4-androstenedione, and luteinizing hormone (LH) plus 4-acetoxy-4-androstenedione on rat follicles in vitro. In regards to testosterone they found that within the first 8 hours 4-acetoxy-4-androstenedione had the ability to directly stimulate testosterone alone and greatly stimulate testosterone in combination with luteinizing hormone (LH). Interestingly enough within the next 16 hours they discovered 4-acetoxy-4-androstenedione alone was stimulating testosterone 3 times as much as luteinizing hormone (LH) while the combination also continued to stimulate testosterone.

Estrogen inhibition was significant with 4-Androsten-4-ol-3, 17-dione acetate alone producing the greatest inhibition at both 8 and 24 hour intervals.

Primobolan Acetate [4-Androsten-4-ol-3beta,17beta-dione Acetate for oral ingestion] is indicated for the long-term promotion of testosterone and regulation of estrogen in humans.

As a dietary supplement, take 1 to 2 tablets 3 times daily. Do not exceed recommended dose. The recommended daily dose in adults is 1-5 mg/kg body weight per day. The usual effective dose is 1-2 mg/kg/day but higher doses may be required, and the dose should be individualized. Response is not often immediate, and a minimum trial of three to six months should be given.

Not to be used with any other medications especially oral hypoglycemic agents ie. Glyburide. Not for use by individuals under the age of 18. Do not use if you are pregnant, contemplating pregnancy or lactating. Consult a physician prior to use if you have any medical condition.